In a study of 37 patients with amyotrophic lateral sclerosis (ALS) (median age: 55 years; median symptom onset: 61 months), researchers found that vitamin D supplementation (2,000 international units daily) was safe over a period of 9 months and may have a beneficial effect on ALSFRS-R scores. Further studies are recommended to determine whether there is a benefit in vitamin D supplementation for all ALS patients.
Note: research indicates that Vitamin D influences respiratory health. Vitamin D is now known to be of physiological importance outside of bone health and calcium homeostasis, and there is mounting evidence that it plays a beneficial role in the prevention and/or treatment of a wide range of diseases. Vitamin D appears capable of inhibiting pulmonary inflammatory responses while enhancing innate defence mechanisms against respiratory pathogens.