Phase I Detoxification Pathway

A reduced Phase I Metabolism reduces the detoxification ability of a variety of xenotoxins including the potentially toxic metals.

Enzymes involved in the Phase I metabolism are Cytochrome P450, and the SOD Enzymes.

While much is known about the role of Phase I enzymes in the metabolism of pharmaceuticals as well as their activation by environmental toxins, the role of Phase I detoxification in clinical practice has received less consideration than the Phase II enzyme systems.